loading...| Preferred Name |
carfilzomib |
|
| Synonyms |
(2S)-N-((1S)-1-benzyl-2-(((1S)-3-methyl-1-(((2R)-2-methyloxiran-2-yl)carbonyl)butyl)amino)-2-oxoethyl)-4-methyl-2-(((2S)-2-((morpholin-4-ylacetyl)amino)-4-phenylbutanoyl)amino)pentanamide |
|
| Definitions |
An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52196" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C52196" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000459751 |
|
| altLabel |
(2S)-N-((1S)-1-benzyl-2-(((1S)-3-methyl-1-(((2R)-2-methyloxiran-2-yl)carbonyl)butyl)amino)-2-oxoethyl)-4-methyl-2-(((2S)-2-((morpholin-4-ylacetyl)amino)-4-phenylbutanoyl)amino)pentanamide Kyprolis PR-171 |
|
| cui |
C1709429 C2001856 C3475268 |
|
| DATE FIRST PUBLISHED |
2005-12-22 |
|
| Date last modified |
2015-07-27 |
|
| definition |
An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52196" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C52196" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C52196 |
|
| notation |
CDR0000459751 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
carfilzomib |
|
| tui |
T109 T116 T121 |