loading...| Preferred Name |
abarelix |
|
| Synonyms |
R-3827 PPI-149 Plenaxis |
|
| Definitions |
A synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2015" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2015" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000415570 |
|
| altLabel |
R-3827 PPI-149 Plenaxis |
|
| CAS Registry |
183552-38-7 |
|
| cui |
C0965390 C0965389 C1527184 C1174732 |
|
| DATE FIRST PUBLISHED |
2005-01-13 |
|
| Date last modified |
2005-01-10 |
|
| definition |
A synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2015" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2015" NCI Thesaurus) |
|
| NCI ID |
C2015 |
|
| notation |
CDR0000415570 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
abarelix |
|
| tui |
T116 T121 |