loading...| Preferred Name |
nelarabine |
|
| Synonyms |
2-amino-6-methoxypurine arabinoside GW506U78 Arranon 2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine 506U78 |
|
| Definitions |
An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1704" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1704" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043260 |
|
| altLabel |
2-amino-6-methoxypurine arabinoside GW506U78 Arranon 2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine 506U78 |
|
| Component of | ||
| cui |
C0759671 C0907349 C1615581 |
|
| Date last modified |
2006-08-31 |
|
| definition |
An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1704" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1704" NCI Thesaurus) |
|
| IND Code |
52611 |
|
| Legacy PDQ ID |
7747 |
|
| LT |
TRD |
|
| NCI ID |
C1704 |
|
| notation |
CDR0000043260 |
|
| NSC Code |
686673 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
nelarabine |
|
| tui |
T114 T121 |