thiotepa

triethylene thiophosphoramide

thiophosphamide

thiophosphoramide

tris(1-aziridinyl)phosphine sulfide

1,1',1''-phosphinothioyldynetrisaziridine

N,N',N''-triethylenethiophosphoramide

WR 45312

tepadina

1,1',1"-phosphinothioylidynetrisaziridine

triethylenethiophosphoramide

thiofosfamide

TSPA

A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C875" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C875" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000042933

triethylene thiophosphoramide

thiophosphamide

thiophosphoramide

tris(1-aziridinyl)phosphine sulfide

1,1',1''-phosphinothioyldynetrisaziridine

N,N',N''-triethylenethiophosphoramide

WR 45312

tepadina

1,1',1"-phosphinothioylidynetrisaziridine

triethylenethiophosphoramide

thiofosfamide

TSPA

52-24-4

http://purl.bioontology.org/ontology/PDQ/CDR0000042112

http://purl.bioontology.org/ontology/PDQ/CDR0000041837

http://purl.bioontology.org/ontology/PDQ/CDR0000039414

http://purl.bioontology.org/ontology/PDQ/CDR0000038848

http://purl.bioontology.org/ontology/PDQ/CDR0000041918

http://purl.bioontology.org/ontology/PDQ/CDR0000420822

http://purl.bioontology.org/ontology/PDQ/CDR0000037781

http://purl.bioontology.org/ontology/PDQ/CDR0000041574

http://purl.bioontology.org/ontology/PDQ/CDR0000039978

http://purl.bioontology.org/ontology/PDQ/CDR0000043037

http://purl.bioontology.org/ontology/PDQ/CDR0000039628

http://purl.bioontology.org/ontology/PDQ/CDR0000041135

http://purl.bioontology.org/ontology/PDQ/CDR0000042950

http://purl.bioontology.org/ontology/PDQ/CDR0000042167

http://purl.bioontology.org/ontology/PDQ/CDR0000042963

http://purl.bioontology.org/ontology/PDQ/CDR0000041436

http://purl.bioontology.org/ontology/PDQ/CDR0000040589

http://purl.bioontology.org/ontology/PDQ/CDR0000041098

http://purl.bioontology.org/ontology/PDQ/CDR0000041773

http://purl.bioontology.org/ontology/PDQ/CDR0000041086

http://purl.bioontology.org/ontology/PDQ/CDR0000041328

http://purl.bioontology.org/ontology/PDQ/CDR0000041316

http://purl.bioontology.org/ontology/PDQ/CDR0000041920

http://purl.bioontology.org/ontology/PDQ/CDR0000042321

http://purl.bioontology.org/ontology/PDQ/CDR0000041087

http://purl.bioontology.org/ontology/PDQ/CDR0000038450

http://purl.bioontology.org/ontology/PDQ/CDR0000041923

http://purl.bioontology.org/ontology/PDQ/CDR0000043032

http://purl.bioontology.org/ontology/PDQ/CDR0000434637

http://purl.bioontology.org/ontology/PDQ/CDR0000043360

http://purl.bioontology.org/ontology/PDQ/CDR0000043577

http://purl.bioontology.org/ontology/PDQ/CDR0000040654

http://purl.bioontology.org/ontology/PDQ/CDR0000039417

http://purl.bioontology.org/ontology/PDQ/CDR0000322038

http://purl.bioontology.org/ontology/PDQ/CDR0000041093

http://purl.bioontology.org/ontology/PDQ/CDR0000039409

http://purl.bioontology.org/ontology/PDQ/CDR0000038854

http://purl.bioontology.org/ontology/PDQ/CDR0000257375

http://purl.bioontology.org/ontology/PDQ/CDR0000040979

http://purl.bioontology.org/ontology/PDQ/CDR0000041914

http://purl.bioontology.org/ontology/PDQ/CDR0000041021

http://purl.bioontology.org/ontology/PDQ/CDR0000039413

http://purl.bioontology.org/ontology/PDQ/CDR0000041239

http://purl.bioontology.org/ontology/PDQ/CDR0000041438

http://purl.bioontology.org/ontology/PDQ/CDR0000040651

http://purl.bioontology.org/ontology/PDQ/CDR0000041993

http://purl.bioontology.org/ontology/PDQ/CDR0000040638

http://purl.bioontology.org/ontology/PDQ/CDR0000041237

http://purl.bioontology.org/ontology/PDQ/CDR0000040903

http://purl.bioontology.org/ontology/PDQ/CDR0000042956

http://purl.bioontology.org/ontology/PDQ/CDR0000041439

http://purl.bioontology.org/ontology/PDQ/CDR0000040788

http://purl.bioontology.org/ontology/PDQ/CDR0000040840

http://purl.bioontology.org/ontology/PDQ/CDR0000042060

http://purl.bioontology.org/ontology/PDQ/CDR0000041077

http://purl.bioontology.org/ontology/PDQ/CDR0000409550

http://purl.bioontology.org/ontology/PDQ/CDR0000042066

http://purl.bioontology.org/ontology/PDQ/CDR0000042827

http://purl.bioontology.org/ontology/PDQ/CDR0000041097

http://purl.bioontology.org/ontology/PDQ/CDR0000041790

http://purl.bioontology.org/ontology/PDQ/CDR0000041922

http://purl.bioontology.org/ontology/PDQ/CDR0000041079

http://purl.bioontology.org/ontology/PDQ/CDR0000043465

http://purl.bioontology.org/ontology/PDQ/CDR0000042640

http://purl.bioontology.org/ontology/PDQ/CDR0000041139

C3531311

C0039871

C1522499

2015-01-12

A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C875" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C875" NCI Thesaurus)

9547

680

TRD

C875

CDR0000042933

6396

Drug/agent

thiotepa

T109

T131

T121