loading...| Preferred Name |
therapeutic testosterone |
|
| Synonyms |
Testostroval |
|
| Definitions |
A synthetic form of the endogenous androgenic steroid testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C862" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C862" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042926 |
|
| altLabel |
Testostroval Testostroval-PA Testolin Testro AQ delta4-androsten-17beta-ol-3-one Testosterone Mertestate Virosterone (17beta)-17-hydroxyandrost-4-en-3-one Testoderm trans-testosterone |
|
| CAS Registry |
58-22-0 |
|
| Component of | ||
| cui |
C1515405 C0723656 C1515404 C0723659 C0723655 C4721537 C1515403 C0701000 |
|
| Date last modified |
2017-12-11 |
|
| definition |
A synthetic form of the endogenous androgenic steroid testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C862" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C862" NCI Thesaurus) |
|
| Legacy PDQ ID |
676 |
|
| LT |
TRD |
|
| NCI ID |
C862 |
|
| notation |
CDR0000042926 |
|
| NSC Code |
9700 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
therapeutic testosterone |
|
| tui |
T125 T109 T121 |