loading...| Preferred Name |
pemetrexed disodium |
|
| Synonyms |
LY 231514 |
|
| Definitions |
The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1533" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1533" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042328 |
|
| altLabel |
LY 231514 MTA multitargeted antifolate Alimta LY231514 L-glutamic acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl) N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt |
|
| CAS Registry |
137281-23-3 150399-23-8 (disodium) |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000420842 http://purl.bioontology.org/ontology/PDQ/CDR0000434621 http://purl.bioontology.org/ontology/PDQ/CDR0000043313 http://purl.bioontology.org/ontology/PDQ/CDR0000043083 http://purl.bioontology.org/ontology/PDQ/CDR0000038011 http://purl.bioontology.org/ontology/PDQ/CDR0000425375 http://purl.bioontology.org/ontology/PDQ/CDR0000305824 http://purl.bioontology.org/ontology/PDQ/CDR0000437780 http://purl.bioontology.org/ontology/PDQ/CDR0000410765 http://purl.bioontology.org/ontology/PDQ/CDR0000438667 |
|
| cui |
C0936142 C0210657 C0251353 C1101816 |
|
| Date last modified |
2017-12-13 |
|
| definition |
The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1533" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1533" NCI Thesaurus) |
|
| Legacy PDQ ID |
5578 |
|
| LT |
TRD |
|
| NCI ID |
C1533 |
|
| notation |
CDR0000042328 |
|
| NSC Code |
698037 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
pemetrexed disodium |
|
| tui |
T109 T121 |