loading...| Preferred Name |
toremifene citrate |
|
| Synonyms |
(Z)-2-[4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate (1:1) |
|
| Definitions |
The citrate salt of a nonsteroidal triphenylethylene antiestrogen. Chemically related to tamoxifen, toremifene is a selective estrogen receptor modulator (SERM). This agent binds competitively to estrogen receptors, thereby interfering with estrogen activity. Toremifene also has intrinsic estrogenic properties, which is manifested depending on the tissue or species. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1756" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1756" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041103 |
|
| altLabel |
(Z)-2-[4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate (1:1) GTx-006 Fareston FC-1157a 2-(p-[(Z)-4-chloro-1,2-diphenyl-1-butenyl]-phenoxy)- N,N-dimethylethylamine citrate (1:1) |
|
| CAS Registry |
89778-27-8 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000043355 http://purl.bioontology.org/ontology/PDQ/CDR0000038196 http://purl.bioontology.org/ontology/PDQ/CDR0000038349 http://purl.bioontology.org/ontology/PDQ/CDR0000042517 |
|
| cui |
C0600382 C0700082 C4721477 C0117339 |
|
| Date last modified |
2017-08-11 |
|
| definition |
The citrate salt of a nonsteroidal triphenylethylene antiestrogen. Chemically related to tamoxifen, toremifene is a selective estrogen receptor modulator (SERM). This agent binds competitively to estrogen receptors, thereby interfering with estrogen activity. Toremifene also has intrinsic estrogenic properties, which is manifested depending on the tissue or species. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1756" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1756" NCI Thesaurus) |
|
| Legacy PDQ ID |
4144 |
|
| LT |
TRD |
|
| NCI ID |
C1756 |
|
| notation |
CDR0000041103 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
toremifene citrate |
|
| tui |
T109 T121 |