loading...| Preferred Name |
eflornithine hydrochloride |
|
| Synonyms |
2-difluoromethylornithine hydrochloride |
|
| Definitions |
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1579" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1579" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039754 |
|
| altLabel |
2-difluoromethylornithine hydrochloride 2-(difluoromethyl)-DL-ornithine hydrochloride, monohydrate Vaniqa alpha-difluoromethylornithine hydrochloride 2-(difluoromethyl)-dl-ornithine hydrochloride, monohydrate MDL 71782 RMI-71782 eflornithine HCl |
|
| CAS Registry |
96020-91-6 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041039 http://purl.bioontology.org/ontology/PDQ/CDR0000039114 http://purl.bioontology.org/ontology/PDQ/CDR0000041712 http://purl.bioontology.org/ontology/PDQ/CDR0000037982 http://purl.bioontology.org/ontology/PDQ/CDR0000041175 http://purl.bioontology.org/ontology/PDQ/CDR0000038355 http://purl.bioontology.org/ontology/PDQ/CDR0000039617 |
|
| cui |
C2711854 C0949215 C1521916 C0282042 C0939525 |
|
| Date last modified |
2017-11-03 |
|
| definition |
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1579" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1579" NCI Thesaurus) |
|
| Legacy PDQ ID |
2415 |
|
| LT |
TRD |
|
| NCI ID |
C1579 |
|
| notation |
CDR0000039754 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
eflornithine hydrochloride |
|
| tui |
T109 T116 T121 |