loading...| Preferred Name |
trimethoprim-sulfamethoxazole |
|
| Synonyms |
Septra SMZ-TMP cotrimoxazole Sulmeprim insozalin Sulfatrim Eslectin trimezole Bactrim Sulfamethoprim TMP-SMX trimedin co-trimoxazole Cotrim |
|
| Definitions |
A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as co-trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthetase. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C909" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C909" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039724 |
|
| altLabel |
Septra SMZ-TMP cotrimoxazole Sulmeprim insozalin Sulfatrim Eslectin trimezole Bactrim Sulfamethoprim TMP-SMX trimedin co-trimoxazole Cotrim |
|
| CAS Registry |
8064-90-2 |
|
| cui |
C1883397 C0699595 C0723514 C0041044 C0591139 C0699584 C1883396 |
|
| Date last modified |
2008-10-06 |
|
| definition |
A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as co-trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthetase. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C909" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C909" NCI Thesaurus) |
|
| Legacy PDQ ID |
2386 |
|
| LT |
TRD |
|
| NCI ID |
C909 |
|
| notation |
CDR0000039724 |
|
| NSC Code |
618652 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
trimethoprim-sulfamethoxazole |
|
| tui |
T109 T121 |