loading...| Preferred Name |
streptonigrin |
|
| Synonyms |
Bruneomycin nigrin 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid STN Rufocromomycin PC-501 BA-163 5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid |
|
| Definitions |
An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C844" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C844" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039703 |
|
| altLabel |
Bruneomycin nigrin 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid STN Rufocromomycin PC-501 BA-163 5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid |
|
| CAS Registry |
3930-19-6 |
|
| cui |
C0038427 C0878534 C0878531 C0878533 |
|
| Date last modified |
2006-12-15 |
|
| definition |
An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C844" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C844" NCI Thesaurus) |
|
| IND Code |
925 |
|
| Legacy PDQ ID |
2363 |
|
| NCI ID |
C844 |
|
| notation |
CDR0000039703 |
|
| NSC Code |
83950 45383 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
streptonigrin |
|
| tui |
T109 T195 |