loading...| Preferred Name |
fenretinide |
|
| Synonyms |
N-(4-hydroxyphenyl)retinamide |
|
| Definitions |
An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1098" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1098" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039582 |
|
| altLabel |
N-(4-hydroxyphenyl)retinamide McN-R-1967 all-trans-N-4'-hydroxyretinanilide 4-hydroxyphenylretinamide all-trans-N-(4-hydroxyphenyl)retinamide 4-HPR fenretinimide 4-(all-trans-retino-yl)aminophenol All-trans-4'-hydroxyretinanilide |
|
| CAS Registry |
65646-68-6 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000037964 http://purl.bioontology.org/ontology/PDQ/CDR0000039638 http://purl.bioontology.org/ontology/PDQ/CDR0000415997 |
|
| cui |
C0750611 C0060197 |
|
| Date last modified |
2010-06-07 |
|
| definition |
An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1098" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1098" NCI Thesaurus) |
|
| IND Code |
40294 |
|
| Legacy PDQ ID |
2237 |
|
| NCI ID |
C1098 |
|
| notation |
CDR0000039582 |
|
| NSC Code |
374551 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
fenretinide |
|
| tui |
T109 T121 |