loading...| Preferred Name |
mitotane |
|
| Synonyms |
Chloditan |
|
| Definitions |
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C664" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C664" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039506 |
|
| altLabel |
Chloditan Mytotan DDD CB-313 Lysodren Khloditan Lisodren 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene 2,2-bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane Ortho,para-DDD o,p'-DDD WR-13045 2,4'-dichlorodiphenyldichloroethane Chlodithane 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane 2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane o,p' - DDD |
|
| CAS Registry |
53-19-0 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000039097 http://purl.bioontology.org/ontology/PDQ/CDR0000405877 http://purl.bioontology.org/ontology/PDQ/CDR0000343771 |
|
| cui |
C0702007 C0702006 C0702004 C0026256 C1513353 C1522709 C1522708 |
|
| Date last modified |
2006-08-29 |
|
| definition |
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C664" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C664" NCI Thesaurus) |
|
| Legacy PDQ ID |
2140 |
|
| LT |
TRD |
|
| NCI ID |
C664 |
|
| notation |
CDR0000039506 |
|
| NSC Code |
38721 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
mitotane |
|
| tui |
T109 T121 |