loading...| Preferred Name |
gallium nitrate |
|
| Synonyms |
WR-135675 |
|
| Definitions |
A hydrated nitrate salt of the group IIIa element gallium with potential use in the treatment of malignancy-associated hypercalcemia. Gallium nitrate localizes preferentially to areas of bone resorption and remodeling and inhibits osteoclast-mediated resorption by enhancing hydroxyapatite crystallization and reduction of bone mineral solubility. This agent also increases calcium and phosphorous deposition into bone and may increase collagen synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1109" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1109" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039249 |
|
| altLabel |
WR-135675 GaN Ganite |
|
| CAS Registry |
13494-90-1 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041991 http://purl.bioontology.org/ontology/PDQ/CDR0000041806 http://purl.bioontology.org/ontology/PDQ/CDR0000042111 |
|
| cui |
C1524019 C0061008 C0720570 |
|
| Date last modified |
2006-12-13 |
|
| definition |
A hydrated nitrate salt of the group IIIa element gallium with potential use in the treatment of malignancy-associated hypercalcemia. Gallium nitrate localizes preferentially to areas of bone resorption and remodeling and inhibits osteoclast-mediated resorption by enhancing hydroxyapatite crystallization and reduction of bone mineral solubility. This agent also increases calcium and phosphorous deposition into bone and may increase collagen synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1109" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1109" NCI Thesaurus) |
|
| IND Code |
10123 |
|
| Legacy PDQ ID |
1871 |
|
| LT |
TRD |
|
| NCI ID |
C1109 |
|
| notation |
CDR0000039249 |
|
| NSC Code |
15200 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
gallium nitrate |
|
| tui |
T197 T130 T121 |