loading...| Preferred Name |
diphenhydramine hydrochloride |
|
| Synonyms |
Bendylate |
|
| Definitions |
The hydrochloride salt form of diphenhydramine, an ethanolamine and first-generation histamine antagonist with anti-allergic activity. Diphenhydramine hydrochloride competitively blocks H1receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C300" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C300" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039163 |
|
| altLabel |
Bendylate Benadryl Eldadryl SK-Diphenhydramine |
|
| CAS Registry |
147-24-0 |
|
| cui |
C1527343 C0700902 C0004963 C0700899 C0700901 |
|
| definition |
The hydrochloride salt form of diphenhydramine, an ethanolamine and first-generation histamine antagonist with anti-allergic activity. Diphenhydramine hydrochloride competitively blocks H1receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C300" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C300" NCI Thesaurus) |
|
| Legacy PDQ ID |
1783 |
|
| LT |
TRD |
|
| NCI ID |
C300 |
|
| notation |
CDR0000039163 |
|
| NSC Code |
33299 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
diphenhydramine hydrochloride |
|
| tui |
T109 T121 |