loading...| Preferred Name |
amphotericin B deoxycholate |
|
| Synonyms |
Fungizone |
|
| Definitions |
The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, resulting in depolarization of the membrane; alterations in cell membrane permeability and leakage of important intracellular components; and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62201" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C62201" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039143 |
|
| altLabel |
Fungizone |
|
| CAS Registry |
58501-21-6 |
|
| Component of | ||
| cui |
C0051761 C0812405 |
|
| Date last modified |
2017-10-23 |
|
| definition |
The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, resulting in depolarization of the membrane; alterations in cell membrane permeability and leakage of important intracellular components; and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62201" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C62201" NCI Thesaurus) |
|
| Legacy PDQ ID |
1763 |
|
| LT |
TRD |
|
| NCI ID |
C62201 |
|
| notation |
CDR0000039143 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
amphotericin B deoxycholate |
|
| tui |
T109 T195 T121 |