acyclovir sodium

2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one monosodium salt

Zovirax for injection

9-[(2-hydroxyethoxy)methyl]guanine monosodium salt

The sodium salt form of acyclovir, a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral DNA polymerase by incorporating into the growing viral DNA chain and terminating further polymerization. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47956" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47956" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000039134

2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one monosodium salt

Zovirax for injection

9-[(2-hydroxyethoxy)methyl]guanine monosodium salt

69657-51-8

http://purl.bioontology.org/ontology/PDQ/CDR0000041048

C0282040

C0592290

2017-10-23

The sodium salt form of acyclovir, a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral DNA polymerase by incorporating into the growing viral DNA chain and terminating further polymerization. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47956" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47956" NCI Thesaurus)

1755

TRD

C47956

CDR0000039134

Drug/agent

acyclovir sodium

T114

T121