loading...| Preferred Name |
ipomeanol |
|
| Synonyms |
1-(3-furanyl)-4-hydroxy-1-pentanone 4-ipomeanol |
|
| Definitions |
A natural toxic furan isolated from a fungus-infected sweet potato (Ipomoea batatas) with potential antineoplastic activity. Ipomeanol is activated by mixed function oxidases in vivo to its epoxide form, an alkylating agent that covalently binds cell macromolecules. This agent causes cell death by a p53-independent mechanism. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C976" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C976" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000038852 |
|
| altLabel |
1-(3-furanyl)-4-hydroxy-1-pentanone 4-ipomeanol |
|
| CAS Registry |
32954-58-8 |
|
| cui |
C0048420 |
|
| definition |
A natural toxic furan isolated from a fungus-infected sweet potato (Ipomoea batatas) with potential antineoplastic activity. Ipomeanol is activated by mixed function oxidases in vivo to its epoxide form, an alkylating agent that covalently binds cell macromolecules. This agent causes cell death by a p53-independent mechanism. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C976" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C976" NCI Thesaurus) |
|
| IND Code |
31371 |
|
| Legacy PDQ ID |
1342 |
|
| NCI ID |
C976 |
|
| notation |
CDR0000038852 |
|
| NSC Code |
349438 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
ipomeanol |
|
| tui |
T109 T123 |