donepezil hydrochloride

1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hydrochloride

The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2603" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2603" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000038109

1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hydrochloride

E-2020

Aricept

120011-70-3

142057-77-0

http://purl.bioontology.org/ontology/PDQ/CDR0000038110

C0527315

C0287816

C0771848

2017-06-02

The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2603" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2603" NCI Thesaurus)

10662

TRD

C2603

CDR0000038109

Drug/agent

donepezil hydrochloride

T109

T121