loading...| Preferred Name |
didanosine |
|
| Synonyms |
dideoxyinosine |
|
| Definitions |
A synthetic nucleoside analogue of deoxyadenosine in which the 3' hydroxyl on the ribose moiety is replaced by a hydrogen atom. In vivo, didanosine is converted to the active triphosphate form, which is incorporated into DNA. The absence of the 3' hydroxyl inhibits DNA elongation because phosphodiester bonds cannot be made with the substituted hydrogen. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C431" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C431" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000037814 |
|
| altLabel |
dideoxyinosine Videx Didanosine EC Videx EC 2',3'-Dideoxyinosine ddI |
|
| CAS Registry |
69655-05-6 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041680 |
|
| cui |
C0592249 C0012133 C0939526 |
|
| definition |
A synthetic nucleoside analogue of deoxyadenosine in which the 3' hydroxyl on the ribose moiety is replaced by a hydrogen atom. In vivo, didanosine is converted to the active triphosphate form, which is incorporated into DNA. The absence of the 3' hydroxyl inhibits DNA elongation because phosphodiester bonds cannot be made with the substituted hydrogen. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C431" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C431" NCI Thesaurus) |
|
| IND Code |
33746 35782 31714 33134 |
|
| Legacy PDQ ID |
1020 |
|
| LT |
TRD |
|
| NCI ID |
C431 |
|
| notation |
CDR0000037814 |
|
| NSC Code |
612049 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
didanosine |
|
| tui |
T114 T121 |