Preferred Name |
cefixime |
|
Synonyms |
Suprax |
|
Definitions |
A broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1100" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1100" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000037809 |
|
altLabel |
Suprax FK-027 FK 027 |
|
Component of | ||
cui |
C0060400 C0752064 C0678177 |
|
Date last modified |
2008-05-27 |
|
definition |
A broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1100" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1100" NCI Thesaurus) |
|
Legacy PDQ ID |
10167 |
|
LT |
TRD |
|
NCI ID |
C1100 |
|
notation |
CDR0000037809 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
cefixime |
|
tui |
T109 T195 |