Prostate Cancer Ontology

Last uploaded: June 3, 2019
Preferred Name

Dutasteride

ID

http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#dutasteride

ChineseLabel

度他雄胺

isDefinedBy

A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver./NCI-GLOSS Definition: A drug used to treat symptoms of an enlarged prostate gland. It is being studied in the treatment of male hair loss and prostate cancer. Avodart blocks enzymes the body needs to make male sex hormones. It is a type of 5-alpha reductase inhibitor.

label

Dutasteride

prefixIRI

ProstateCancer:dutasteride

prefLabel

Dutasteride

reference

NCI Thesaurus Code:C47503

synonyms

GG 745

Avodart/Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

DUTASTERIDE

GG745

dutasteride

alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide

Dutasteride

URL

https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C47503

subClassOf

http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#5a-Reductase_Inhibition

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503 NCIT LOOM
http://purl.bioontology.org/ontology/UATC/G04CB02 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C108373 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004621 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004621 DMTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148790 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#48591 OCHV LOOM
http://purl.jp/bio/4/id/200906017639116383 IOBC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000479183 PDQ LOOM
http://stirdf.jst.go.jp/id/200907068774861843 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI LOOM
http://purl.bioontology.org/ontology/NDDF/009824 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/D000068538 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0754659 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/385572003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4021371 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/228790 RXNORM LOOM
http://www.drugbank.ca/drugs/DB01126 FTC LOOM