loading...| Preferred Name |
B-cell chronic lymphocytic leukemia |
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| Synonyms |
B-cell chronic lymphoid leukemia |
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| Definitions |
B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma (see this term), and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia (see these terms). The clinical course is extremely heterogeneous with survival ranging from a few months to several decades. |
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| ID |
http://www.orpha.net/ORDO/Orphanet_67038 |
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| alternative_term |
B-cell chronic lymphoid leukemia Small lymphocytic lymphoma B-CLL |
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| definition |
B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma (see this term), and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia (see these terms). The clinical course is extremely heterogeneous with survival ranging from a few months to several decades. |
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| definition_citation |
Orphanet |
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| expertlink |
https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=67038 |
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| has_age_of_onset |
Adult |
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| has_inheritance |
Not applicable Multigenic/multifactorial |
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| hasDbXref |
OMIM:609630 OMIM:109543 MedDRA:10008958 OMIM:612558 OMIM:612559 OMIM:612557 ICD-10:C91.1 UMLS:C0023434 ICD-11:2A82.0 MeSH:D015451 OMIM:151400 |
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| label |
B-cell chronic lymphocytic leukemia |
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| notation |
ORPHA:67038 |
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| part_of | ||
| prefixIRI |
ORDO:Orphanet_67038 |
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| prefLabel |
B-cell chronic lymphocytic leukemia |
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| present_in |
Europe AND has_point_prevalence_average_value : 48.0 AND has_point_prevalence_range : 1-5 / 10 000 France AND has_annual_incidence_average_value : 7.05 AND has_annual_incidence_range : 1-9 / 100 000 |
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| treeView | ||
| subClassOf |