loading...| Preferred Name |
Dactinomycin |
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| Synonyms |
Actinomycin D actinomycin-D ACT-D Meractinomycin Actinomycin I1 Actinomycin X 1 Dactinomycin chemical actinomycin C1 Actinomycin-[thr-val-pro-sar-meval] Actinomycin IV DACT Actinomycin A IV Dactinomycine |
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| Definitions |
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) (source : MSH) |
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| ID |
http://doe-generated-ontology.com/OntoAD#C0010934 |
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| altLabel |
Actinomycin D actinomycin-D ACT-D Meractinomycin Actinomycin I1 Actinomycin X 1 Dactinomycin chemical actinomycin C1 Actinomycin-[thr-val-pro-sar-meval] Actinomycin IV DACT Actinomycin A IV Dactinomycine |
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| contraindicated_drug | ||
| definition |
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) (source : MSH) |
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| hiddenLabel |
Dactinomycin |
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| may_treat | ||
| prefixIRI |
OntoAD:C0010934 |
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| prefLabel |
Dactinomycin |
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| subClassOf |
http://doe-generated-ontology.com/OntoAD#C0033671 http://doe-generated-ontology.com/OntoAD#C0001259 http://doe-generated-ontology.com/OntoAD#C0279516 |