Preferred Name |
Cladribine |
|
Synonyms |
2-chloro-2'-deoxy-beta-adenosine Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine CldAdo InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N 2-chlorodeoxyadenosine 2ClAdo cladribinum (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol C10H12ClN5O3 InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1 cladribina 2-chloro-deoxyadenosine cladribine 2-CdA 2-chloro-2'-deoxyadenosine Cladribine |
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Definitions |
2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_567361 |
|
database_cross_reference |
DrugBank:DB00242 ChEMBL:18570408 Beilstein:624220 ChEMBL:17526755 Patent:EP173059 ChemIDplus:4291-63-8 ChEMBL:567361 KEGG DRUG:4291-63-8 ChEMBL:568373 Wikipedia:Cladribine KEGG DRUG:D01370 Patent:US4760137 |
|
definition |
2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia. |
|
has_alternative_id |
CHEBI:31407 CHEBI:568373 |
|
has_exact_synonym |
2-chloro-2'-deoxyadenosine Cladribine |
|
has_related_synonym |
2-chloro-2'-deoxy-beta-adenosine Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine CldAdo InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N 2-chlorodeoxyadenosine 2ClAdo cladribinum (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol C10H12ClN5O3 InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1 cladribina 2-chloro-deoxyadenosine cladribine 2-CdA |
|
has_RxCUI |
44157 |
|
id |
CHEBI:567361 |
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imported from | ||
label |
cladribine Cladribine |
|
notation |
CHEBI:567361 |
|
prefLabel |
Cladribine |
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subClassOf |