loading...| Preferred Name |
Secobarbital |
|
| Synonyms |
5-(pentan-2-yl)-5-(prop-2-en-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione secobarbital secobarbitone secobarbitalum (+-)-secobarbital 5-(1-methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione Seconal 5-allyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione quinalbarbitone 5-allyl-5-(1-methylbutyl)pyrimidine-2,4,6(1H,3H,5H)-trione 5-allyl-5-(1-methylbutyl)barbituric acid Hyptran Pramil Immenoctal Immenox Synate Quinalspan Seotal Quinalbarbital Meballymal sodium Somosal Evrronal Sebar Secobarbitone Novosecobarb Trisomnin Sedutain Hypotrol Seco 8 Quinalbarbitone Evronal Sodium Meballymal Imesonal Meballymalum Quinalbarbitone sodium |
|
| Definitions |
Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug. It possesses anaesthetic, anticonvulsant, sedative and hypnotic properties. In the United Kingdom, it was known as Quinalbarbitone. Pharmacology: Secobarbital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation. Mechanism of action: Secobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. Drug type: Approved. Small Molecule. Drug category: Adjuvants. Adjuvants, Anesthesia. Barbiturates. GABA Modulators. Hypnotics and Sedatives A member of the class of barbiturates that is barbituric acid in which the hydrogens at position 5 are substituted by prop-2-en-1-yl and pentan-2-yl groups. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_9073 |
|
| charge |
0 |
|
| createdDate |
March 5, 2010 |
|
| database_cross_reference |
Wikipedia:Secobarbital KEGG:D00430 Beilstein:225330 CAS:76-73-3 DrugBank:DB00418 HMDB:HMDB0014562 Drug_Central:2428 Reaxys:225330 Gmelin:283703 |
|
| definition |
Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug. It possesses anaesthetic, anticonvulsant, sedative and hypnotic properties. In the United Kingdom, it was known as Quinalbarbitone. Pharmacology: Secobarbital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation. Mechanism of action: Secobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. Drug type: Approved. Small Molecule. Drug category: Adjuvants. Adjuvants, Anesthesia. Barbiturates. GABA Modulators. Hypnotics and Sedatives |
|
| formula |
C12H18N2O3 |
|
| has characteristic | ||
| has exact synonym |
5-(pentan-2-yl)-5-(prop-2-en-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione secobarbital |
|
| has functional parent | ||
| has role | ||
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
secobarbitone secobarbitalum (+-)-secobarbital 5-(1-methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione Seconal 5-allyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione quinalbarbitone 5-allyl-5-(1-methylbutyl)pyrimidine-2,4,6(1H,3H,5H)-trione 5-allyl-5-(1-methylbutyl)barbituric acid secobarbital |
|
| hasExternalSource |
DB00418 |
|
| id |
CHEBI:9073 |
|
| in_subset | ||
| inchi |
InChI=1S/C12H18N2O3/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17) |
|
| inchikey |
KQPKPCNLIDLUMF-UHFFFAOYSA-N |
|
| is conjugate acid of | ||
| label |
Secobarbital secobarbital |
|
| mass |
238.28300 |
|
| modifiedDate |
April 15, 2010 |
|
| monoisotopicmass |
238.13174 |
|
| notation |
CHEBI:9073 |
|
| prefLabel |
Secobarbital |
|
| smiles |
CCCC(C)C1(CC=C)C(=O)NC(=O)NC1=O |
|
| synonym |
Hyptran Pramil Immenoctal Immenox Synate Quinalspan Seotal Quinalbarbital Meballymal sodium Somosal Evrronal Sebar Secobarbitone Novosecobarb Trisomnin Sedutain Hypotrol Seco 8 Quinalbarbitone Evronal Sodium Meballymal Imesonal Meballymalum Quinalbarbitone sodium |
|
| subClassOf |