Preferred Name

Amiloride [Chemical/Ingredient]

Synonyms

Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-

ID

http://purl.bioontology.org/ontology/NDFRT/N0000006772

altLabel

Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-

Amiloride

Contraindicating class of

http://purl.bioontology.org/ontology/NDFRT/N0000146253

http://purl.bioontology.org/ontology/NDFRT/N0000155572

http://purl.bioontology.org/ontology/NDFRT/N0000155571

cui

C0002502

Ingredient of

http://purl.bioontology.org/ontology/NDFRT/N0000147699

http://purl.bioontology.org/ontology/NDFRT/N0000020156

http://purl.bioontology.org/ontology/NDFRT/N0000151097

MESH DEFINITION

A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

MESH DUI

D000584

MeSH name

Amiloride

MESH UI

M0000906

NDFRT kind

INGREDIENT_KIND

notation

N0000006772

NUI

N0000006772

prefLabel

Amiloride [Chemical/Ingredient]

tui

T109

T121

subClassOf

http://purl.bioontology.org/ontology/NDFRT/N0000007565

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http://purl.bioontology.org/ontology/CSP/2507-2912 CRISP CUI
http://purl.bioontology.org/ontology/LNC/LP16024-9 LOINC CUI
http://purl.bioontology.org/ontology/UATC/C03DB01 ATC CUI
http://purl.bioontology.org/ontology/VANDF/4019603 VANDF CUI
http://purl.bioontology.org/ontology/LNC/MTHU006775 LOINC CUI
http://purl.bioontology.org/ontology/SNMI/C-72410 SNMI CUI
http://purl.bioontology.org/ontology/SNOMEDCT/87395005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RXNORM/644 RXNORM CUI
http://purl.bioontology.org/ontology/RCD/x01Qu RCD CUI
http://purl.bioontology.org/ontology/NDDF/004861 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387503008 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D000584 MESH CUI