Preferred Name

Simvastatin [Chemical/Ingredient]

Synonyms

Synvinolin

ID

http://purl.bioontology.org/ontology/NDFRT/N0000005842

altLabel

Synvinolin

Simvastatin

Contraindicating class of

http://purl.bioontology.org/ontology/NDFRT/N0000148264

http://purl.bioontology.org/ontology/NDFRT/N0000148609

http://purl.bioontology.org/ontology/NDFRT/N0000148436

http://purl.bioontology.org/ontology/NDFRT/N0000186113

http://purl.bioontology.org/ontology/NDFRT/N0000165855

http://purl.bioontology.org/ontology/NDFRT/N0000158212

http://purl.bioontology.org/ontology/NDFRT/N0000148479

http://purl.bioontology.org/ontology/NDFRT/N0000022055

http://purl.bioontology.org/ontology/NDFRT/N0000166069

http://purl.bioontology.org/ontology/NDFRT/N0000165847

http://purl.bioontology.org/ontology/NDFRT/N0000158211

http://purl.bioontology.org/ontology/NDFRT/N0000180951

cui

C0074554

C4082576

Ingredient of

http://purl.bioontology.org/ontology/NDFRT/N0000165896

http://purl.bioontology.org/ontology/NDFRT/N0000193670

http://purl.bioontology.org/ontology/NDFRT/N0000165802

http://purl.bioontology.org/ontology/NDFRT/N0000164174

http://purl.bioontology.org/ontology/NDFRT/N0000166017

http://purl.bioontology.org/ontology/NDFRT/N0000165801

http://purl.bioontology.org/ontology/NDFRT/N0000165803

http://purl.bioontology.org/ontology/NDFRT/N0000165996

http://purl.bioontology.org/ontology/NDFRT/N0000148200

http://purl.bioontology.org/ontology/NDFRT/N0000166016

http://purl.bioontology.org/ontology/NDFRT/N0000165800

http://purl.bioontology.org/ontology/NDFRT/N0000193669

http://purl.bioontology.org/ontology/NDFRT/N0000164280

http://purl.bioontology.org/ontology/NDFRT/N0000022372

MESH DEFINITION

A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.

MESH DUI

D019821

MeSH name

Simvastatin

MESH UI

M0029425

NDFRT kind

INGREDIENT_KIND

notation

N0000005842

NUI

N0000005842

prefLabel

Simvastatin [Chemical/Ingredient]

tui

T109

T121

subClassOf

http://purl.bioontology.org/ontology/NDFRT/N0000007106

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http://purl.bioontology.org/ontology/SNMI/C-80812 SNMI CUI
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000005842 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000005842 OCVDAE LOOM
http://purl.bioontology.org/ontology/LNC/LP171640-8 LOINC CUI
http://purl.bioontology.org/ontology/SCTSPA/387584000 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/36567 RXNORM CUI
http://purl.bioontology.org/ontology/NDDF/003621 NDDF CUI
http://purl.bioontology.org/ontology/VANDF/4020400 VANDF CUI
http://purl.bioontology.org/ontology/CSP/5001-0024 CRISP CUI
http://purl.bioontology.org/ontology/CSP/5001-0024 CRISP CUI
http://purl.bioontology.org/ontology/SCTSPA/96304005 SCTSPA CUI
http://purl.bioontology.org/ontology/MSHFRE/D019821 MSHFRE CUI
http://purl.bioontology.org/ontology/RCD/bxd.. RCD CUI
http://purl.bioontology.org/ontology/RCD/bxd.. RCD CUI
http://purl.bioontology.org/ontology/MESH/D019821 MESH CUI
http://purl.bioontology.org/ontology/MESH/D019821 MESH CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000455226 PDQ CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387584000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/UATC/C10AA01 ATC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/96304005 SNOMEDCT CUI