loading...| Preferred Name |
Amyotrophic Lateral Sclerosis [Disease/Finding] |
|
| Synonyms |
Lou-Gehrigs Disease Lou Gehrig's Disease Lou Gehrig Disease Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Gehrig's Disease Charcot Disease ALS (Amyotrophic Lateral Sclerosis) |
|
| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000000376 |
|
| altLabel |
Lou-Gehrigs Disease Lou Gehrig's Disease Lou Gehrig Disease Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Gehrig's Disease Charcot Disease ALS (Amyotrophic Lateral Sclerosis) |
|
| cui |
C0002736 |
|
| May be treated by |
http://purl.bioontology.org/ontology/NDFRT/N0000193465 http://purl.bioontology.org/ontology/NDFRT/N0000193536 |
|
| MESH DEFINITION |
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) |
|
| MESH DUI |
D000690 |
|
| MeSH name |
Amyotrophic Lateral Sclerosis |
|
| MESH UI |
M0001056 |
|
| NDFRT kind |
DISEASE_KIND |
|
| notation |
N0000000376 |
|
| NUI |
N0000000376 |
|
| prefLabel |
Amyotrophic Lateral Sclerosis [Disease/Finding] |
|
| SNOMED CID |
86044005 |
|
| tui |
T047 |
|
| subClassOf |