TDP-43 Proteinopathies [Disease/Finding]

TDP-43 Proteinopathies

http://purl.bioontology.org/ontology/NDFRT/N0000181303

TDP-43 Proteinopathies

C2718017

Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.

D057177

TDP-43 Proteinopathies

M0534988

DISEASE_KIND

N0000181303

N0000181303

TDP-43 Proteinopathies [Disease/Finding]

T047

http://purl.bioontology.org/ontology/NDFRT/N0000003949