National Drug File - Reference Terminology - Clozapine [Chemical/Ingredient] - Classes | NCBO BioPortal

National Drug File - Reference Terminology

Last uploaded: July 6, 2018

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Preferred Name	Clozapine [Chemical/Ingredient]
Synonyms	Clozapine
ID	http://purl.bioontology.org/ontology/NDFRT/N0000006585
altLabel	Clozapine 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
cui	C0009079
Ingredient of	http://purl.bioontology.org/ontology/NDFRT/N0000182009 http://purl.bioontology.org/ontology/NDFRT/N0000182010 http://purl.bioontology.org/ontology/NDFRT/N0000188354 http://purl.bioontology.org/ontology/NDFRT/N0000022332 http://purl.bioontology.org/ontology/NDFRT/N0000165135 http://purl.bioontology.org/ontology/NDFRT/N0000191697 http://purl.bioontology.org/ontology/NDFRT/N0000190818 http://purl.bioontology.org/ontology/NDFRT/N0000190819 http://purl.bioontology.org/ontology/NDFRT/N0000022238 http://purl.bioontology.org/ontology/NDFRT/N0000147608 http://purl.bioontology.org/ontology/NDFRT/N0000190821 http://purl.bioontology.org/ontology/NDFRT/N0000192204 http://purl.bioontology.org/ontology/NDFRT/N0000190820 http://purl.bioontology.org/ontology/NDFRT/N0000022419 http://purl.bioontology.org/ontology/NDFRT/N0000180145 http://purl.bioontology.org/ontology/NDFRT/N0000182011 http://purl.bioontology.org/ontology/NDFRT/N0000181784 http://purl.bioontology.org/ontology/NDFRT/N0000022397 http://purl.bioontology.org/ontology/NDFRT/N0000191694 http://purl.bioontology.org/ontology/NDFRT/N0000163436 http://purl.bioontology.org/ontology/NDFRT/N0000022239 http://purl.bioontology.org/ontology/NDFRT/N0000192203 http://purl.bioontology.org/ontology/NDFRT/N0000181785 http://purl.bioontology.org/ontology/NDFRT/N0000189531 http://purl.bioontology.org/ontology/NDFRT/N0000191696 http://purl.bioontology.org/ontology/NDFRT/N0000180146 http://purl.bioontology.org/ontology/NDFRT/N0000165136 http://purl.bioontology.org/ontology/NDFRT/N0000163434 http://purl.bioontology.org/ontology/NDFRT/N0000189506 http://purl.bioontology.org/ontology/NDFRT/N0000163435 http://purl.bioontology.org/ontology/NDFRT/N0000190822 http://purl.bioontology.org/ontology/NDFRT/N0000163433 http://purl.bioontology.org/ontology/NDFRT/N0000022241 http://purl.bioontology.org/ontology/NDFRT/N0000022240 http://purl.bioontology.org/ontology/NDFRT/N0000191695 http://purl.bioontology.org/ontology/NDFRT/N0000181786 http://purl.bioontology.org/ontology/NDFRT/N0000181783
MESH DEFINITION	A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
MESH DUI	D003024
MeSH name	Clozapine
MESH UI	M0004649
NDFRT kind	INGREDIENT_KIND
notation	N0000006585
NUI	N0000006585
prefLabel	Clozapine [Chemical/Ingredient]
tui	T109 T121
subClassOf	http://purl.bioontology.org/ontology/NDFRT/N0000007962

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Delete	Mapping To	Ontology	Source
	http://purl.bioontology.org/ontology/MSHFRE/D003024	MSHFRE	CUI
	http://purl.bioontology.org/ontology/RXNORM/2626	RXNORM	CUI
	http://purl.bioontology.org/ontology/SNMI/C-63420	SNMI	CUI
	http://purl.bioontology.org/ontology/VANDF/4019488	VANDF	CUI
	http://purl.bioontology.org/ontology/CSP/0314-4862	CRISP	CUI
	http://purl.bioontology.org/ontology/ATC/N05AH02	ATC	CUI
	http://purl.bioontology.org/ontology/VANDF/4040180	VANDF	CUI
	http://purl.bioontology.org/ontology/LNC/LP17236-8	LOINC	CUI
	http://purl.bioontology.org/ontology/RCD/d4l..	RCD	CUI
	http://purl.bioontology.org/ontology/MESH/D003024	MESH	CUI
	http://purl.bioontology.org/ontology/NDDF/003526	NDDF	CUI
	http://purl.bioontology.org/ontology/SCTSPA/387568001	SCTSPA	CUI
	http://purl.bioontology.org/ontology/SNOMEDCT/96221003	SNOMEDCT	CUI
	http://purl.bioontology.org/ontology/SCTSPA/96221003	SCTSPA	CUI
	http://purl.bioontology.org/ontology/VANDF/4037345	VANDF	CUI
	http://purl.bioontology.org/ontology/VANDF/4036908	VANDF	CUI
	http://purl.bioontology.org/ontology/LNC/MTHU060461	LOINC	CUI
	http://purl.bioontology.org/ontology/VANDF/4037056	VANDF	CUI
	http://purl.bioontology.org/ontology/SNOMEDCT/387568001	SNOMEDCT	CUI