National Drug File - Reference Terminology

Last uploaded: July 6, 2018
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Preferred Name

Simvastatin [Chemical/Ingredient]
Synonyms

Simvastatin

Synvinolin
ID

http://purl.bioontology.org/ontology/NDFRT/N0000005842
altLabel

Simvastatin

Synvinolin
Contraindicating class of

http://purl.bioontology.org/ontology/NDFRT/N0000165847

http://purl.bioontology.org/ontology/NDFRT/N0000165855

http://purl.bioontology.org/ontology/NDFRT/N0000158212

http://purl.bioontology.org/ontology/NDFRT/N0000158211

http://purl.bioontology.org/ontology/NDFRT/N0000180951

http://purl.bioontology.org/ontology/NDFRT/N0000166069

http://purl.bioontology.org/ontology/NDFRT/N0000148479

http://purl.bioontology.org/ontology/NDFRT/N0000148609

http://purl.bioontology.org/ontology/NDFRT/N0000148436

http://purl.bioontology.org/ontology/NDFRT/N0000022055

http://purl.bioontology.org/ontology/NDFRT/N0000148264

http://purl.bioontology.org/ontology/NDFRT/N0000186113
cui

C4082576

C0074554
Ingredient of

http://purl.bioontology.org/ontology/NDFRT/N0000165896

http://purl.bioontology.org/ontology/NDFRT/N0000165800

http://purl.bioontology.org/ontology/NDFRT/N0000022372

http://purl.bioontology.org/ontology/NDFRT/N0000164174

http://purl.bioontology.org/ontology/NDFRT/N0000164280

http://purl.bioontology.org/ontology/NDFRT/N0000166017

http://purl.bioontology.org/ontology/NDFRT/N0000148200

http://purl.bioontology.org/ontology/NDFRT/N0000193669

http://purl.bioontology.org/ontology/NDFRT/N0000166016

http://purl.bioontology.org/ontology/NDFRT/N0000165802

http://purl.bioontology.org/ontology/NDFRT/N0000165996

http://purl.bioontology.org/ontology/NDFRT/N0000165803

http://purl.bioontology.org/ontology/NDFRT/N0000193670

http://purl.bioontology.org/ontology/NDFRT/N0000165801
MESH DEFINITION

A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
MESH DUI

D019821
MeSH name

Simvastatin
MESH UI

M0029425
NDFRT kind

INGREDIENT_KIND
notation

N0000005842
NUI

N0000005842
prefLabel

Simvastatin [Chemical/Ingredient]
tui

T109

T121
subClassOf

http://purl.bioontology.org/ontology/NDFRT/N0000007106
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