loading...| Preferred Name |
Kernicterus [Disease/Finding] |
|
| Synonyms |
Encephalopathy, Hyperbilirubinemic |
|
| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000001744 |
|
| altLabel |
Encephalopathy, Hyperbilirubinemic Hyperbilirubinemic Encephalopathy Kernicterus Encephalopathy, Bilirubin Bilirubin Encephalopathy |
|
| cui |
C0022610 |
|
| MESH DEFINITION |
A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613) |
|
| MESH DUI |
D007647 |
|
| MeSH name |
Kernicterus |
|
| MESH UI |
M0011977 |
|
| NDFRT kind |
DISEASE_KIND |
|
| notation |
N0000001744 |
|
| NUI |
N0000001744 |
|
| prefLabel |
Kernicterus [Disease/Finding] |
|
| SNOMED CID |
50143004 |
|
| tui |
T047 |
|
| subClassOf |