loading...| Preferred Name |
Cobicistat |
|
| Synonyms |
2,7,10,12-Tetraazatridecanoic Acid, 12-Methyl-13-(2-(1-methylethyl)-4-thiazolyl)-9-(2-(4-morpholinyl)ethyl)-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-Thiazolylmethyl Ester, (3R,6R,9S)- COBICISTAT Cobicistat GS 9350 Tybost |
|
| Definitions |
A cytochrome P450 3A (CYP3A) inhibitor that can be used to enhance the pharmacokinetic profile of certain anti-HIV-1 agents. Upon administration, cobicistat inhibits the liver enzyme CYP3A4 and limits the breakdown of co-administered agents that are metabolized by CYP3A4, and increases the concentration, systemic exposure and efficacy of the co-administered agent. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97360 |
|
| CAS_Registry |
1004316-88-4 |
|
| Chemical_Formula |
C40H53N7O5S2 |
|
| code |
C97360 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A cytochrome P450 3A (CYP3A) inhibitor that can be used to enhance the pharmacokinetic profile of certain anti-HIV-1 agents. Upon administration, cobicistat inhibits the liver enzyme CYP3A4 and limits the breakdown of co-administered agents that are metabolized by CYP3A4, and increases the concentration, systemic exposure and efficacy of the co-administered agent. |
|
| Display_Name |
Cobicistat |
|
| FDA_UNII_Code |
LW2E03M5PG |
|
| FULL_SYN |
2,7,10,12-Tetraazatridecanoic Acid, 12-Methyl-13-(2-(1-methylethyl)-4-thiazolyl)-9-(2-(4-morpholinyl)ethyl)-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-Thiazolylmethyl Ester, (3R,6R,9S)- COBICISTAT Cobicistat GS 9350 Tybost |
|
| label |
Cobicistat |
|
| NCI_Drug_Dictionary_ID |
810556 |
|
| Preferred_Name |
Cobicistat |
|
| prefixIRI |
Thesaurus:C97360 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C3177235 |
|
| subClassOf |