National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Hyaluronidase

Synonyms

Hyaluronidase

HYALURONIDASE (BOVINE)

Hyaluronoglucosaminidase

Hyaluronidase (Bovine)

Definitions

An injectable enzyme with potential adjuvant activity. Upon subcutaneous administration, hyaluronidase modifies the permeability of connective tissue by hydrolyzing hyaluronic acid. This temporarily decreases interstitial viscosity and allows drugs that are co-injected to spread rapidly through the interstitial space, thereby facilitating absorption and/or distribution of the co-injected agents.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87576

CAS_Registry

9001-54-1

code

C87576

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An injectable enzyme with potential adjuvant activity. Upon subcutaneous administration, hyaluronidase modifies the permeability of connective tissue by hydrolyzing hyaluronic acid. This temporarily decreases interstitial viscosity and allows drugs that are co-injected to spread rapidly through the interstitial space, thereby facilitating absorption and/or distribution of the co-injected agents.

FDA_UNII_Code

8KOG53Z5EM

FULL_SYN

Hyaluronidase

HYALURONIDASE (BOVINE)

Hyaluronoglucosaminidase

Hyaluronidase (Bovine)

label

Hyaluronidase

Preferred_Name

Hyaluronidase

prefixIRI

Thesaurus:C87576

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0020197

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2140

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