National Cancer Institute Thesaurus

Last uploaded: June 25, 2019
Preferred Name

Sulindac

Synonyms

Aflodac

Arthrocine

Artribid

Clisundac

Sulreuma

Reumofil

Sulinol

cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid

MK-231

SULINDAC

Sulindac Sulfoxide

Reumyl

Algocetil

Clinoril

(Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid

Sudac

Citireuma

Novo-Sundac

Apo-Sulin

sulindac

Imbaral

Sulindac

Definitions

A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C850

Accepted_Therapeutic_Use_For

Arthritis; inflammatory conditions

ALT_DEFINITION

A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer.

CAS_Registry

38194-50-2

CHEBI_ID

CHEBI:9352

Chemical_Formula

C20H17FO3S

code

C850

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)

Display_Name

Sulindac

FDA_UNII_Code

184SNS8VUH

FULL_SYN

Aflodac

Arthrocine

Artribid

Clisundac

Sulreuma

Reumofil

Sulinol

cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid

MK-231

SULINDAC

Sulindac Sulfoxide

Reumyl

Algocetil

Clinoril

(Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid

Sudac

Citireuma

Novo-Sundac

Apo-Sulin

sulindac

Imbaral

Sulindac

label

Sulindac

Legacy_Concept_Name

Sulindac

PDQ_Closed_Trial_Search_ID

41538

PDQ_Open_Trial_Search_ID

41538

Preferred_Name

Sulindac

prefixIRI

ncit:C850

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0038792

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

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Delete Mapping To Ontology Source
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013467 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146307 NDFRT LOOM
http://www.co-ode.org/ontologies/galen#Sulindac GALEN LOOM
http://purl.bioontology.org/ontology/RCD/j2f.. RCD LOOM
http://scai.fraunhofer.de/AlzheimerOntology#sulindac ADO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.486.875 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D013467 MESH LOOM
http://stirdf.jst.go.jp/id/200907040615001920 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4017957 VANDF LOOM
http://data.bnf.fr/ark:/12148/cb12562840g FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041538 PDQ LOOM
http://purl.bioontology.org/ontology/LNC/LP18100-5 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.486.875 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 EFO LOOM
http://d-nb.info/gnd/4358401-9 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/RXNORM/10237 RXNORM LOOM
http://id.loc.gov/authorities/subjects/sh85130323 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387513000 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906008974470052 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003386 LOINC LOOM
http://www.drugbank.ca/drugs/DB00605 FTC LOOM
http://purl.bioontology.org/ontology/SNMI/C-60440 SNMI LOOM
http://purl.bioontology.org/ontology/UATC/M01AB02 ATC LOOM