loading...| Preferred Name |
Lacosamide |
|
| Synonyms |
(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide Harkoseride ADD 234037 Erlosamide LACOSAMIDE Lacosamide SPM 927 Vimpat |
|
| Definitions |
A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C83859 |
|
| CAS_Registry |
175481-36-4 |
|
| Chemical_Formula |
C13H18N2O3 |
|
| code |
C83859 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity. |
|
| Display_Name |
Lacosamide |
|
| FDA_UNII_Code |
563KS2PQY5 |
|
| FULL_SYN |
(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide Harkoseride ADD 234037 Erlosamide LACOSAMIDE Lacosamide SPM 927 Vimpat |
|
| label |
Lacosamide |
|
| NCI_Drug_Dictionary_ID |
712043 |
|
| PDQ_Closed_Trial_Search_ID |
712043 |
|
| PDQ_Open_Trial_Search_ID |
712043 |
|
| Preferred_Name |
Lacosamide |
|
| prefixIRI |
Thesaurus:C83859 |
|
| PubMedID_Primary_Reference |
17395176 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1311230 |
|
| subClassOf |