National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ambrisentan

Synonyms

(+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic Acid

AMBRISENTAN

Ambrisentan

BSF-208075

LU-208075

Letairis

Pulmonext

Volibris

Definitions

An orally bioavailable, selective antagonist of the endothelin type-A (ETA) receptor that may be used for the treatment of pulmonary arterial hypertension (PAH). Upon administration, ambrisentan targets and binds to ETA receptor, which prevents the binding of endothelin-1 (ET-1) to the ETA receptor and ET-1/ETA-mediated vasoconstriction and cell proliferation. This may lead to vasodilation. ET-1 concentrations are increased in plasma as well as lung tissue in PAH, and ET-1 may play a key role in the pathogenesis of PAH.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72694

CAS_Registry

177036-94-1

Chemical_Formula

C22H22N2O4

code

C72694

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An orally bioavailable, selective antagonist of the endothelin type-A (ETA) receptor that may be used for the treatment of pulmonary arterial hypertension (PAH). Upon administration, ambrisentan targets and binds to ETA receptor, which prevents the binding of endothelin-1 (ET-1) to the ETA receptor and ET-1/ETA-mediated vasoconstriction and cell proliferation. This may lead to vasodilation. ET-1 concentrations are increased in plasma as well as lung tissue in PAH, and ET-1 may play a key role in the pathogenesis of PAH.

FDA_UNII_Code

HW6NV07QEC

FULL_SYN

(+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic Acid

AMBRISENTAN

Ambrisentan

BSF-208075

LU-208075

Letairis

Pulmonext

Volibris

label

Ambrisentan

Legacy Concept Name

Ambrisentan

Preferred_Name

Ambrisentan

prefixIRI

Thesaurus:C72694

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1176329

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28334

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C270

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