National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Tetracaine

Synonyms

2-(Dimethylamino)ethyl p-(butylamino)benzoate

Benzoic Acid, 4-(Butylamino)-, 2-(Dimethylamino)ethyl Ester

Tetracaine

TETRACAINE

Definitions

A benzoate ester with anesthetic properties. Upon administration, tetracaine reversibly binds voltage-gated sodium ion channels in neuronal cell membranes and inhibits sodium influx. This prevents the initiation and conduction of nerve impulses, and stabilizes neuronal membranes. This results in a loss of sensation, and thereby provides analgesia and anesthesia.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66590

CAS_Registry

94-24-6

CHEBI_ID

CHEBI:9468

Chemical_Formula

C15H24N2O2

code

C66590

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A benzoate ester with anesthetic properties. Upon administration, tetracaine reversibly binds voltage-gated sodium ion channels in neuronal cell membranes and inhibits sodium influx. This prevents the initiation and conduction of nerve impulses, and stabilizes neuronal membranes. This results in a loss of sensation, and thereby provides analgesia and anesthesia.

FDA_UNII_Code

0619F35CGV

FULL_SYN

2-(Dimethylamino)ethyl p-(butylamino)benzoate

Benzoic Acid, 4-(Butylamino)-, 2-(Dimethylamino)ethyl Ester

Tetracaine

TETRACAINE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75104

label

Tetracaine

Legacy_Concept_Name

Tetracaine

PDQ_Closed_Trial_Search_ID

787099

PDQ_Open_Trial_Search_ID

787099

Preferred_Name

Tetracaine

prefixIRI

ncit:C66590

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0039629

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C245

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/VANDF/4019456 VANDF LOOM
http://purl.bioontology.org/ontology/MESH/D013748 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013748 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/10391 RXNORM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000787099 PDQ LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12129 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.100.050.500.968 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/N01BA03 ATC LOOM
http://purl.bioontology.org/ontology/UATC/C05AD02 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147578 NDFRT LOOM
http://purl.bioontology.org/ontology/NDDF/001361 NDDF LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006160 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006160 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006160 DMTO LOOM
http://purl.jp/bio/4/id/200906086738943919 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP16285-6 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU018291 LOINC LOOM
http://stirdf.jst.go.jp/id/200907029003547696 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0039629 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.127.020.937.968 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/S01HA03 ATC LOOM
http://purl.bioontology.org/ontology/SNMI/C-6B750 SNMI LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006154 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006154 DMTO LOOM
http://purl.bioontology.org/ontology/UATC/D04AB06 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_9468 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9468 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9468 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9468 DRON LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387309008 SNOMEDCT LOOM