National Cancer Institute Thesaurus

Last uploaded: March 26, 2019
Preferred Name

Niclosamide

Synonyms

Benzamide, 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-

Niclosamide

Salicylanilide, 2',5-Dichloro-4'-nitro-

NICLOSAMIDE

Definitions

An orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the expression of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation. This inhibits AR/STAT3-mediated signaling and prevents expression of STAT3 target genes. Altogether, this may inhibit growth of AR-V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted therapies.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66240

CAS_Registry

50-65-7

Chemical_Formula

C13H8Cl2N2O4

code

C66240

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

An orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the expression of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation. This inhibits AR/STAT3-mediated signaling and prevents expression of STAT3 target genes. Altogether, this may inhibit growth of AR-V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted therapies.

Display_Name

Niclosamide

FDA_UNII_Code

8KK8CQ2K8G

FULL_SYN

Benzamide, 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-

Niclosamide

Salicylanilide, 2',5-Dichloro-4'-nitro-

NICLOSAMIDE

label

Niclosamide

Legacy_Concept_Name

Niclosamide

PDQ_Closed_Trial_Search_ID

775866

PDQ_Open_Trial_Search_ID

775866

Preferred_Name

Niclosamide

prefixIRI

ncit:C66240

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0699963

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C250

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http://purl.bioontology.org/ontology/UATC/P02DA01 ATC LOOM
http://purl.bioontology.org/ontology/NDDF/002990 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_7553 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7553 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_7553 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7553 CHEBI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387334008 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.199.860.470 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-56A20 SNMI LOOM
http://purl.obolibrary.org/obo/DRON_00015957 DRON LOOM
http://purl.obolibrary.org/obo/dinto_DB06803 DINTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.793.650.470 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D009534 MESH LOOM
http://stirdf.jst.go.jp/id/200907057768018725 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4018264 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146594 NDFRT LOOM
http://www.co-ode.org/ontologies/galen#Niclosamide GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/5975000 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009534 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/7402 RXNORM LOOM
http://purl.jp/bio/4/id/200906015889627488 IOBC LOOM
http://purl.jp/bio/4/id/200906015889627488 IOBC LOOM