National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Mezlocillin

Synonyms

MEZLOCILLIN

Mezlin

Mezlocillin

Definitions

A broad-spectrum, beta-lactam penicillin antibiotic with antibacterial activity. Mezlocillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts the final stage of bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and eventually causing cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C653

CAS_Registry

51481-65-3

CHEBI_ID

CHEBI:6919

Chemical_Formula

C21H25N5O8S2

code

C653

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A broad-spectrum, beta-lactam penicillin antibiotic with antibacterial activity. Mezlocillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts the final stage of bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and eventually causing cell lysis.

FDA_UNII_Code

OH2O403D1G

FULL_SYN

MEZLOCILLIN

Mezlin

Mezlocillin

label

Mezlocillin

Legacy_Concept_Name

Mezlocillin

PDQ_Closed_Trial_Search_ID

39505

PDQ_Open_Trial_Search_ID

39505

Preferred_Name

Mezlocillin

prefixIRI

ncit:C653

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0025893

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1558

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008802 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP16017-3 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4019838 VANDF LOOM
http://stirdf.jst.go.jp/id/200907090949858919 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008455 LOINC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039505 PDQ LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.084.737.750.050.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-54B20 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.750.750.050.500 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_6919 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6919 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_6919 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6919 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6919 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6919 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_6919 NIFSTD LOOM
http://purl.jp/bio/4/id/200906011760090520 IOBC LOOM
http://purl.obolibrary.org/obo/ARO_3000639 ARO LOOM
http://purl.bioontology.org/ontology/MESH/D008802 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/6927 RXNORM LOOM
http://purl.obolibrary.org/obo/DRON_00011109 DRON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.750.750.050.500 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.108.750.750.050.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/e36.. RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.260.825.750.050.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147926 NDFRT LOOM
http://www.co-ode.org/ontologies/galen#Mezlocillin GALEN LOOM
http://purl.bioontology.org/ontology/UATC/J01CA10 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387446008 SNOMEDCT LOOM