National Cancer Institute Thesaurus

Last uploaded: June 25, 2019
Preferred Name

Auranofin

Synonyms

AURANOFIN

Auranofin

Ridaura

Definitions

An orally available, lipophilic, organogold compound, used to treat rheumatoid arthritis, with anti-inflammatory and potential antineoplastic activities. Auranofin interacts with selenocysteine residue within the redox-active domain of mitochondrial thioredoxin reductase (TrxR), thereby blocking the activity of TrxR. As a result, this agent induces mitochondrial oxidative stress leading to the induction of apoptosis. Furthermore, this agent strongly inhibits the JAK1/STAT3 signal transduction pathway, thereby suppressing expression of immune factors involved in inflammation. TrxR, overexpressed in many cancer cell types, inhibits apoptosis, promotes cell growth and survival and plays a role in resistance to chemotherapy; TrxR catalyzes the reduction of oxidized thioredoxin (Trx) and plays a central role in regulating cellular redox homeostasis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65242

CAS_Registry

34031-32-8

CHEBI_ID

CHEBI:2922

Chemical_Formula

C20H34AuO9PS

code

C65242

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

An orally available, lipophilic, organogold compound, used to treat rheumatoid arthritis, with anti-inflammatory and potential antineoplastic activities. Auranofin interacts with selenocysteine residue within the redox-active domain of mitochondrial thioredoxin reductase (TrxR), thereby blocking the activity of TrxR. As a result, this agent induces mitochondrial oxidative stress leading to the induction of apoptosis. Furthermore, this agent strongly inhibits the JAK1/STAT3 signal transduction pathway, thereby suppressing expression of immune factors involved in inflammation. TrxR, overexpressed in many cancer cell types, inhibits apoptosis, promotes cell growth and survival and plays a role in resistance to chemotherapy; TrxR catalyzes the reduction of oxidized thioredoxin (Trx) and plays a central role in regulating cellular redox homeostasis.

Display_Name

Auranofin

FDA_UNII_Code

3H04W2810V

FULL_SYN

AURANOFIN

Auranofin

Ridaura

label

Auranofin

Legacy_Concept_Name

Auranofin

PDQ_Closed_Trial_Search_ID

710355

PDQ_Open_Trial_Search_ID

710355

Preferred_Name

Auranofin

prefixIRI

ncit:C65242

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0699923

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C574

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.691.675.249.150 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/1227 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387100001 SNOMEDCT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146358 ODAE LOOM
http://purl.obolibrary.org/obo/DRON_00013467 ODNAE LOOM
http://purl.obolibrary.org/obo/DRON_00013467 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146358 NDFRT LOOM
http://purl.bioontology.org/ontology/SNMI/C-B8210 SNMI LOOM
http://www.co-ode.org/ontologies/galen#Auranofin GALEN LOOM
http://purl.bioontology.org/ontology/UATC/M01CB03 ATC LOOM
http://purl.bioontology.org/ontology/NDDF/002398 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D001310 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/j56.. RCD LOOM
http://purl.jp/bio/4/id/200906031675805988 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_2922 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2922 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2922 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2922 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2922 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_2922 CHEBI LOOM
http://bmi.utah.edu/ontologies/peontology/C0004320 RAO LOOM
http://purl.bioontology.org/ontology/MESH/D001310 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4018014 VANDF LOOM
http://www.drugbank.ca/drugs/DB00995 FTC LOOM
http://id.loc.gov/authorities/subjects/sh85009540 FAST-TOPICAL LOOM