National Cancer Institute Thesaurus

Last uploaded: May 28, 2019
Preferred Name

Adalimumab

Synonyms

ADALIMUMAB

Adalimumab

Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimer

LU200134

D2E7

Humira

Definitions

A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65216

Accepted_Therapeutic_Use_For

Rheumatoid Arthritis, Crohn's Disease, Ankylosing Spondylitis, Psoriatic Arthritis

CAS_Registry

331731-18-1

code

C65216

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases.

FDA_UNII_Code

FYS6T7F842

FULL_SYN

ADALIMUMAB

Adalimumab

Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimer

LU200134

D2E7

Humira

label

Adalimumab

Legacy_Concept_Name

Adalimumab

PDQ_Closed_Trial_Search_ID

791684

PDQ_Open_Trial_Search_ID

791684

Preferred_Name

Adalimumab

prefixIRI

ncit:C65216

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1122087

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20401

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http://purl.bioontology.org/ontology/VANDF/4021370 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU047400 LOINC LOOM
http://purl.bioontology.org/ontology/NDDF/009871 NDDF LOOM
http://purl.obolibrary.org/obo/DRON_00018971 DRON LOOM
http://purl.bioontology.org/ontology/UATC/L04AB04 ATC LOOM
http://purl.obolibrary.org/obo/dinto_DB00051 DINTO LOOM
http://purl.bioontology.org/ontology/LNC/LP173592-9 LOINC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004952 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004952 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004952 DMTO LOOM
http://purl.bioontology.org/ontology/MESH/D000068879 MESH LOOM
http://bmi.utah.edu/ontologies/peontology/C1122087 RAO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148789 NDFRT LOOM
http://purl.bioontology.org/ontology/RXNORM/327361 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/407317001 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906069625827996 IOBC LOOM
http://www.drugbank.ca/drugs/DB00051 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C453439 RH-MESH LOOM