National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Cyanocobalamin

Synonyms

cyanocobalamin

Vitamin B12

Calomist

Cyanocobalamin

CYANOCOBALAMIN

Berubigen

Betalin 12

Cobavite

Definitions

A cobalt-containing coordination compound generated by intestinal microbes, and a natural water-soluble vitamin of the B-complex family that must combine with Intrinsic Factor for absorption by the intestine. Cyanocobalamin is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. B12 improves iron functions in the metabolic cycle and assists folic acid in choline synthesis. B12 metabolism is interconnected with that of folic acid. Vitamin B12 deficiency causes pernicious anemia, megaloblastic anemia, and neurologic lesions.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64333

ALT_DEFINITION

A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Cyanocobalamin helps make red blood cells, DNA, RNA, energy, and tissues, and keeps nerve cells healthy. It is found in liver, meat, eggs, poultry, shellfish, milk, and milk products. Cyanocobalamin is water-soluble (can dissolve in water) and must be taken in every day. Not enough cyanocobalamin can cause certain types of anemia (a condition in which the number of red blood cells is below normal) and neurologic disorders. It is being studied with folate in the prevention and treatment of some types of cancer.

CAS_Registry

68-19-9

CHEBI_ID

CHEBI:17439

Chemical_Formula

C63H89CoN14O14P

code

C64333

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A cobalt-containing coordination compound generated by intestinal microbes, and a natural water-soluble vitamin of the B-complex family that must combine with Intrinsic Factor for absorption by the intestine. Cyanocobalamin is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. B12 improves iron functions in the metabolic cycle and assists folic acid in choline synthesis. B12 metabolism is interconnected with that of folic acid. Vitamin B12 deficiency causes pernicious anemia, megaloblastic anemia, and neurologic lesions.

FDA_UNII_Code

P6YC3EG204

FULL_SYN

cyanocobalamin

Vitamin B12

Calomist

Cyanocobalamin

CYANOCOBALAMIN

Berubigen

Betalin 12

Cobavite

label

Cyanocobalamin

Legacy_Concept_Name

Cyanocobalamin

NSC_Code

80365

PDQ_Closed_Trial_Search_ID

40295

PDQ_Open_Trial_Search_ID

40295

Preferred_Name

Cyanocobalamin

prefixIRI

ncit:C64333

Semantic_Type

Pharmacologic Substance

Vitamin

UMLS_CUI

C1964367

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C939

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNOMEDCT/419382002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP15262-6 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Cyanocobalamin GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4021896 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/B03BA01 ATC LOOM
http://purl.obolibrary.org/obo/dinto_DB00115 DINTO LOOM
http://purl.bioontology.org/ontology/VANDF/4017441 VANDF LOOM
http://www.drugbank.ca/drugs/DB00115 FTC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040295 PDQ LOOM
http://purl.bioontology.org/ontology/LNC/LP32549-5 LOINC LOOM