National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Rimantadine

Synonyms

1-(1-Adamantyl)ethylamin

Tricyclo(3.3.1.1(sup 3,7))decane-1-methanamine, alpha-methyl-

alpha-Methyl-1-adamantanemethylamine

Rimantadine

HSDB 7438

RIMANTADINE

Definitions

A cyclic amine and alpha-methyl derivative of amantadine with antiviral activity. Although the exact mechanism of action of rimantadine is not understood, this agent appears to exert its antiviral effect against influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the uncoating of the virus and subsequent release of infectious viral nucleic acids into the cytoplasm of infected cells.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61927

CAS_Registry

13392-28-4

Chemical_Formula

C12H21N

code

C61927

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A cyclic amine and alpha-methyl derivative of amantadine with antiviral activity. Although the exact mechanism of action of rimantadine is not understood, this agent appears to exert its antiviral effect against influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the uncoating of the virus and subsequent release of infectious viral nucleic acids into the cytoplasm of infected cells.

FDA_UNII_Code

0T2EF4JQTU

FULL_SYN

1-(1-Adamantyl)ethylamin

Tricyclo(3.3.1.1(sup 3,7))decane-1-methanamine, alpha-methyl-

alpha-Methyl-1-adamantanemethylamine

Rimantadine

HSDB 7438

RIMANTADINE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61928

label

Rimantadine

Legacy_Concept_Name

Rimantadine

Preferred_Name

Rimantadine

prefixIRI

ncit:C61927

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0035629

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C281

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