National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Cyclophosphamide Anhydrous
Synonyms

Cyclophosphamide Anhydrous

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide

2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide

CYCLOPHOSPHAMIDE ANHYDROUS
Definitions

The anhydrous form of cyclophosphamide, a synthetic nitrogen mustard alkylating agent, with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to active metabolites including phosphoramide mustard, which binds to and crosslinks DNA and RNA, thereby inhibiting DNA replication and protein synthesis. This agent, at low doses, is also a potent immunosuppressant primarily by depleting T-regulatory cells.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61694
CAS_Registry

50-18-0
CHEBI_ID

CHEBI:4027
Chemical_Formula

C7H15Cl2N2O2P
code

C61694
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
Contributing_Source

FDA

GDC
DEFINITION

The anhydrous form of cyclophosphamide, a synthetic nitrogen mustard alkylating agent, with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to active metabolites including phosphoramide mustard, which binds to and crosslinks DNA and RNA, thereby inhibiting DNA replication and protein synthesis. This agent, at low doses, is also a potent immunosuppressant primarily by depleting T-regulatory cells.
FDA_UNII_Code

6UXW23996M
FULL_SYN

Cyclophosphamide Anhydrous

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide

2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide

CYCLOPHOSPHAMIDE ANHYDROUS
Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909
label

Cyclophosphamide Anhydrous
Legacy Concept Name

Cyclophosphamide_Anhydrous
Maps_To

Cyclophosphamide Anhydrous
Preferred_Name

Cyclophosphamide Anhydrous
prefixIRI

Thesaurus:C61694
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C1880207
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C574

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C697
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