National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Ceftibuten

Synonyms

Ceftibuten

CEFTIBUTEN

Definitions

A semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Ceftibuten binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61666

CAS_Registry

97519-39-6

CHEBI_ID

CHEBI:3510

Chemical_Formula

C15H14N4O6S2

code

C61666

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Ceftibuten binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

FDA_UNII_Code

IW71N46B4Y

FULL_SYN

Ceftibuten

CEFTIBUTEN

label

Ceftibuten

Legacy_Concept_Name

Ceftibuten

Preferred_Name

Ceftibuten

prefixIRI

ncit:C61666

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0055014

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNOMEDCT/387535008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/005181 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/D000077722 MESH LOOM
http://purl.bioontology.org/ontology/RCD/e6n.. RCD LOOM
http://purl.obolibrary.org/obo/DRON_00010441 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148426 NDFRT LOOM
http://purl.jp/bio/4/id/200906049460887300 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/J01DD14 ATC LOOM
http://stirdf.jst.go.jp/id/200907081897356317 IOBC LOOM
http://www.co-ode.org/ontologies/galen#Ceftibuten GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C054360 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-535B0 SNMI LOOM
http://purl.bioontology.org/ontology/RXNORM/20492 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/LP17268-1 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4020946 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_3510 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3510 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3510 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3510 GENEPIO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU015664 LOINC LOOM
http://purl.obolibrary.org/obo/ARO_3000648 ARO LOOM