National Cancer Institute Thesaurus

Last uploaded: May 28, 2019
Preferred Name

Ifosfamide

Synonyms

Iphosphamid

Isoendoxan

Isophosphamide

IFO

Holoxan

Iso-Endoxan

ifosfamide

2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine

MJF 9325

MJF-9325

Ifex

3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide

Ifolem

Z 4942

Ifosfamide

N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

Cyfos

Naxamide

Tronoxal

Asta Z 4942

Seromida

Asta Z-4942

Z-4942

Holoxane

Ifomide

IFO-Cell

Iphosphamide

Ifosfamidum

IFOSFAMIDE

IFX

Ifoxan

Mitoxana

Ifomida

Definitions

A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C564

Accepted_Therapeutic_Use_For

Breast cancer; gastric carcinoma; lung cancer; lymphocytic leukemias; lymphoma; Hodgkins and Non-Hodgkins; ovarian cancer; pancreatic carcinoma; sarcomas; testicular cancer

ALT_DEFINITION

A drug that is used with other drugs to treat germ cell testicular cancer that did not respond to previous treatment with other drugs. It is also being studied in the treatment of other types of cancer. Ifex attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent and a type of antimetabolite.

CAS_Registry

3778-73-2

CHEBI_ID

CHEBI:5864

Chemical_Formula

C7H15Cl2N2O2P

code

C564

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04)

Display_Name

Ifosfamide

FDA_UNII_Code

UM20QQM95Y

FULL_SYN

Iphosphamid

Isoendoxan

Isophosphamide

IFO

Holoxan

Iso-Endoxan

ifosfamide

2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine

MJF 9325

MJF-9325

Ifex

3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide

Ifolem

Z 4942

Ifosfamide

N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

Cyfos

Naxamide

Tronoxal

Asta Z 4942

Seromida

Asta Z-4942

Z-4942

Holoxane

Ifomide

IFO-Cell

Iphosphamide

Ifosfamidum

IFOSFAMIDE

IFX

Ifoxan

Mitoxana

Ifomida

label

Ifosfamide

Legacy_Concept_Name

Ifosfamide

NSC_Code

109724

PDQ_Closed_Trial_Search_ID

40024

PDQ_Open_Trial_Search_ID

40024

Preferred_Name

Ifosfamide

prefixIRI

ncit:C564

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0020823

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C697

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007069 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/5657 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/LP65841-6 LOINC LOOM
http://purl.jp/bio/4/id/200906013041937026 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/L01AA06 ATC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040024 PDQ LOOM
http://purl.bioontology.org/ontology/VANDF/4019476 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.705.672.500.243.250 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Ifosfamide GALEN LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147596 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP65832-5 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.526.728.650.730.243.250 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/h17.. RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.533.500 RH-MESH LOOM
http://www.ifomis.org/acgt/1.0#Ifosfamide ACGT-MO LOOM
http://doe-generated-ontology.com/OntoPneumo#Ifosfamide ONTOPNEUMO LOOM
http://stirdf.jst.go.jp/id/200907032215822116 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 CHEBI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386904003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/D007069 MESH LOOM
http://purl.bioontology.org/ontology/CSP/4000-0210 CRISP LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147596 ODAE LOOM