National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Etoricoxib

Synonyms

ETORICOXIB

MK-0663

5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl) Pyridine

Arcoxia

Etoricoxib

L-791456

Definitions

A synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52188

CAS_Registry

202409-33-4

CHEBI_ID

CHEBI:6339

Chemical_Formula

C18H15ClN2O2S

code

C52188

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

Contributing_Source

FDA

DEFINITION

A synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.

FDA_UNII_Code

WRX4NFY03R

FULL_SYN

ETORICOXIB

MK-0663

5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl) Pyridine

Arcoxia

Etoricoxib

L-791456

label

Etoricoxib

Legacy_Concept_Name

Etoricoxib

PDQ_Closed_Trial_Search_ID

462092

PDQ_Open_Trial_Search_ID

462092

Preferred_Name

Etoricoxib

prefixIRI

ncit:C52188

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0972314

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

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