Preferred Name |
Metronidazole Hydrochloride |
|
Synonyms |
Metronidazole Hydrochloride Flagyl I.V. METRONIDAZOLE HYDROCHLORIDE Flagyl Metro I.V. SC 32642 Satric |
|
Definitions |
The hydrochloride salt of a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48005 |
|
ALT_DEFINITION |
A drug that is used to treat infection and is being studied in the treatment of cancer. It is type of antibacterial, antiprotozoal, and anthelmintic. |
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CAS_Registry |
69198-10-3 |
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CHEBI_ID |
CHEBI:50687 |
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Chemical_Formula |
C6H9N3O3.HCl |
|
code |
C48005 |
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Concept_In_Subset | ||
Contributing_Source |
FDA |
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DEFINITION |
The hydrochloride salt of a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. |
|
FDA_UNII_Code |
76JC1633UF |
|
FULL_SYN |
Metronidazole Hydrochloride Flagyl I.V. METRONIDAZOLE HYDROCHLORIDE Flagyl Metro I.V. SC 32642 Satric |
|
Has_Free_Acid_Or_Base_Form | ||
label |
Metronidazole Hydrochloride |
|
Legacy Concept Name |
Metronidazole_Hydrochloride |
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NCI_Drug_Dictionary_ID |
39503 |
|
PDQ_Closed_Trial_Search_ID |
39503 |
|
PDQ_Open_Trial_Search_ID |
39503 |
|
Preferred_Name |
Metronidazole Hydrochloride |
|
prefixIRI |
Thesaurus:C48005 |
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Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0282239 |
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subClassOf |