loading...| Preferred Name |
Oxcarbazepine |
|
| Synonyms |
OXCARBAZEPINE 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide Oxcarbazepine Trileptal |
|
| Definitions |
A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47643 |
|
| CAS_Registry |
28721-07-5 |
|
| CHEBI_ID |
CHEBI:7824 |
|
| Chemical_Formula |
C15H12N2O2 |
|
| code |
C47643 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses. |
|
| Display_Name |
Oxcarbazepine |
|
| FDA_UNII_Code |
VZI5B1W380 |
|
| FULL_SYN |
OXCARBAZEPINE 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide Oxcarbazepine Trileptal |
|
| Is_Value_For_GDC_Property | ||
| label |
Oxcarbazepine |
|
| Legacy Concept Name |
Oxcarbazepine |
|
| Maps_To |
Oxcarbazepine |
|
| NCI_Drug_Dictionary_ID |
758784 |
|
| PDQ_Closed_Trial_Search_ID |
758784 |
|
| PDQ_Open_Trial_Search_ID |
758784 |
|
| Preferred_Name |
Oxcarbazepine |
|
| prefixIRI |
Thesaurus:C47643 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0069751 |
|
| subClassOf |